Prof Yuval Ebenstein promoted to Full Professor
School of Chemistry
Visit the NanoBioPhotonix Lab of Prof. Ebenstein to learn more about their latest research.
Areas of focus include:
Single molecule genomics by optical mapping:
We create optical barcodes containing genetic and epigenetic information by labeling long chromosomal DNA molecules with fluorescent markers. Nano-fluidic channels are used to stretch the DNA by flow or electric field and the barcode is directly visualized by single molecule imaging. We are aiming to apply SR imaging techniques in order to increase the resolution and allow detection of genomic aberrations.
Epigenetic analysis technologies:
Epigenetics is one of the most exciting and fast growing fields in biology. It links biological signatures with mental or environmental conditions previously not believed to be quantified by physical means. We develop new methods for sequencing, targeted and global analysis of various epigenetgic markers. We use these novel methods in order to study epigenetic alterations related to disease. We are also very interested in the physiological interface between nature and nurture, biology and psychology, body and spirit.
High-throughput single molecule detection:
We develop optical methods and nano-biosensors for detection of rare analytes and weakly interacting biomolecules. Our emphasis is on ultrasensitive detection and quantification of clinical biomarkers. To achieve this aim we are developing a micro-lens-array based optical setup that can detect single molecule fluorescence from hundreds of confocal excitation volumes in parallel.
We are also active in development of single-molecule counting schemes and development of high resolution imaging techniques and specialized contrast agents that utilize fluorescence, plasmonics and energy transfer for super-resolution (SR) imaging.